Abstract
Introduction: Proton pump inhibitors (PPIs) are most prescribed medication classes and have similar efficacy between generic and brand names. PPIs are used for treatment upper GIT disorders. The aim of the present study was to evaluate the effectiveness and safety of proton pump inhibitors (PPIs). Methods: A cross sectional study conducted randomly on pharmacies, patients and Doctors to collect a data regarding the effectiveness and safely use of PPI through predesigned questionnaire containing information about dosage, types, side effect, effectiveness and safety of PPIs. The collected data was analysis by using Chi-square for determine the significant differences at α < 0.05. Result: The result of present study revealed numbers of points in which the questionnaire were intended for pharmacies, patients and doctors knowledge, effectiveness and safety of PPIs. The data gathered from pharmacy shown PPI dispensed without prescription (P< 0.05) in dose of 20 mg of omeprazole and for treatment of gastritis, stomachache and on medication use (P< 0.05). No side effect or any problem, safe, and effective of PPIs was from patients seeking PPIs to the drug dispensers. Furthermore, questionnaire for patients whom seeking treatment shown some similarity to pharmacies answers, however lack the knowledge about side effect of PPIs, and PPIs withdraw among patients. PPIs was found to be used by patients due to the advices of friends (P< 0.05). The last part in this study was doctors involved in which some common similarity were also identified between doctors, patients and pharmacies responses. Although, Doctors responses were revealed that PPIs should be used by prescription in single dose of common types of PPIs (P< 0.05). Conclusion: Due to the short time use of PPIs have been reported. This study suggested that, even no side effect and highly effective of PPIs reported, the PPIs should be monitoring and use under prescription.
Highlights
Proton pump inhibitors (PPIs) are most prescribed medication classes and have similar efficacy between generic and brand names
Questionnaire for patients whom seeking treatment shown some similarity to pharmacies answers, lack the knowledge about side effect of PPIs, and PPIs withdraw among patients
Study designed and sample size A Cross sectional survey conducted from beginning of November 2020 to the end of March 2021 on randomly selected patients suffering from upper GIT disorder visiting doctors, a doctors and pharmacies for receiving PPI in Benghazi city, Libya
Summary
Proton pump inhibitors (PPIs) are most prescribed medication classes and have similar efficacy between generic and brand names. PPIs are used for treatment upper GIT disorders. The aim of the present study was to evaluate the effectiveness and safety of proton pump inhibitors (PPIs). Proton pump inhibitors (PPIs) have been identified in 1990s [1] and defined as class of drugs effect on lowering stomach acid production via irreversibly inhibiting the H+/K+ ATPase proton pump of the stomach [2]. Proton pump inhibitors (PPIs) is considered among the most commonly prescribed medications [4]. The long term use of PPIs are associated with increased risk for gastric cancer, dementia, diarrhea pneumonia, increased gastric infection, gastric neuroendocrine tumor, hypomagnesemia, colon cancer, spontaneous bacterial peritonitis and hepatic encephalopathy and bacteria overgrowth of small intestine [7, 8]
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