EVALUATE THE DISTRIBUTION OF HLA-DQA1 ALLELES ON KING PEOPLE IN GOOD HEALTH AND LIVER CANCER PATIENTS, LING CANCER PATIENTS LIVING IN THE AREA OF BINH TRI THIEN

Abstract

Objectives: To evaluate the distribution of HLA-DQA1 alleles on Kinh nationality in heathy and in cancer of liver and lung of the area of Binh Tri Thien. Subjects and Methods: PCR-SSP technique is used for analyzing antigen HLA-DQA1 system of 318 healthy people are Kinh people, and 38 patients with HCC and 37 patients ưith lung cancer, aged 7-80, living in Binh Tri Thien area. Results: The frequence found HLA-DQA1 alleles common on Kinh nationality in Binh Tri Thien region is 90.6%, the alleles were found with the highest frequency of DQA1 * 0101 (25.2%), DQA1 * 0104 (20.4%), has two alleles are not found completely that are DQA1 * 0302, DQA1 * 0401 alleles. Only in the Kinh nationality people in Binh Tri Thien region found DQA1 * 0104 allele. For liver cancer, carriers of DQA1 * 0301 allele can protect against the risk of liver cancer (OR = 1.67, 95% of CI from 1,04 to 2,25). In contrast, carriers of DQA1 * 0501 allele may be a signal for liver cancer risk (OR = 4.18, 95% of CI from 3,19 to 5,05). For lung cancer, carriers of allele DQA1 * 0101 and DQA1 * 0102 allele has the ability to protect against the risk of lung cancer (OR = 1.12 and OR = 1.18 for each corresponding allele.) However, carriers of DQA1 * 0501 allele may indicate lung cancer risk (OR = 3.22, 95% of CI from 2,24 to 4,15). Conclusion: The alleles were found with the highest frequency that are DQA1 * 0101, DQA1 * 0104, only in the Kinh people of Binh Tri Thien region found allele HLA-DQA1 * 0104. DQA1 * 0301 allele may be able to protect against the risk of liver cancer, which carriy of DQA1 * 0501 allele may be a signal of the risk of liver cancer, who carry alleles DQA1 * 0101 and DQA1 * 0102 allele can protection to avoid the risk of lung cancer, who had a DQA1 * 0501 allele may signal risk of lung cancer.