Evaluate The Correlation Serum Afamin Level With Some Biochemical Parameters In The Sera Of Patients With Type 2 Diabetes Mellitus

Abstract

The purpose of the study was to investigate the relationship between afamin and lipid profiles, renal function, liver enzymes, oxidative stress, and patients with type 2 diabetes (T2DM). The study included 150 adults divided into two groups: 75 patients with type 2 diabetes mellitus and 75 healthy subjects of both sexes; their ages ranged between (35-65 years). Biochemical parameters included (afamin (AFM), Total Cholesterol, HDL, LDL, TG, VLDL, AST, ALT, ALP, urea, creatinine, MDA, GSH, uric acid, and calcium/phosphorous ratio were measured. Results: the results of the study showed that a significant positive correlation was found between the level of AFM with LDL (r=0.479; p=0.01) TG (r=0.256; p=0.027), ALT (r=0.326; p=0.01), AST (r=0.325; p=0.01), ALP (r=0.427; p=0.01), creatinine (r=0.277; p=0.016), urea (r=0.436; p=0.01), Uric acid (r=0.477; p=0.01) and MDA (r=0.463; p=0.01). In contrast, afamin negatively correlates with GSH (r=-0.460; p=0.01). Conclusion: Afamin is associated positively with LDL and TG, liver enzyme (ALT, AST, and ALP), renal function (creatinine and urea), and oxidative stress (Uric acid and MDA), while it negatively correlates with GSH; thus, increasing the level of afamin may induce type 2 diabetes and its complications, such as fat metabolism, which has consequences related to heart disease and atherosclerosis. In addition, a high level of afamin may lead to disturbances in liver enzymes, kidney function, and oxidative stress.