Evaluate microbial profile and IL-17 level in transmission transfusion infection patients

Abstract

Transfusion-transmitted infections (TTIs) an important causes of morbidity and mortality among recipients of blood /blood products since it among the essential vehicles for infectious agents that lead to disability or death. So this study aimed to evaluate the important causative agents and the role of IL-17 in progressive disease . A Case-control study was performed to 100 patients with Transfusion blood attended to AL-Sadder teaching hospital with group of 30 healthy individual as control. Blood sample was collected from all patients and control. IL-17 level were measured by enzyme-linked immunosorbent assay (ELISA). The result shown that Hemodialysis patients 54 (54%) patient from which 40(74%) suffering from TTI, HCV were most common causative agents with 42 % and the male recorded 63%. While 46(46%) patients with thalassemia from which 32(70%) were TTI and HCV a most common pathogen with 19(41 %), the male higher than female with frequency (65%). In conclusion: This result explain that HCV infected more than non-infected HD patients and the serum IL-17 level increased significantly in HD patients with HCV, then patients without HCV infection in comparison with healthy control group.