Abstract
Garcia RM, Romero .JJ, Ocanlpo CL, Auro OA. Tec Pecu Mex 1999;37(3)23-30. One of the main problems that greatly affect.'i aquaculture, both in fresh and salt water, is the presence of pathogenic organisms such as the Vibrionaceae family. Vibrio fluorens produces in fish bleeding at the base of the fins, mouth and branquiae, and inflanlfiation and necrosis of skin and muscle. When fish survive the infection, scar tissue remains reducing the market value. In this bioassay, the activity of a new cephaquinolone was evaluated in experinlentally infected tilapia. This antibiotic is the result of the joining through a carboxile bonding of a fluoroquinolone with a cephalosporine, thIL'i providing a wider spectrunl of activity. This cephaquinolone was administered at different concentratioIL.' in the water and also mixed with the food. It was observed that when the antibiotic was added, mortality decreased. The effective 50% dose in food was 6.6 fig/kg while in water it was 20.5 fig/kg. Effet.1iveness, of the drug proved to be 1.9 times greater in food than in water.
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