Abstract
The aim of this study was to evaluate in vitro the response within 96 hrs of gingival fibroblasts cultures against different endodontic sealers, The results obtained at intervals of 0, 1, 2, 3, 6, 24, 48, 72 and 96 hrs were used to determine the cytotoxicity of the endodontic sealers. Gingival fibroblast cultures without root canal sealer and with Sealapex were used as negative and positive controls, respectively. The results were compared with negative controls and statistically analyzed with the Dunnett t test (p ≤ 0.05). The endodontic Sealers investigated were ProRoot MTA gray and white, CPM, MTA Angelus, Sealapex and GuttaFlow. The results showed that eventhough ProRoot MTA (gray and white) MTA Angelus, CPM and GuttaFlow proved to have a lower cytotoxic potential than Sealapex, no statistical significant differences were established.
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