Abstract
Eutypenoids A–C (1–3), pimarane diterpenoid alkaloid and two ring A rearranged pimarane diterpenoids, were isolated from the culture of Eutypella sp. D-1 obtained from high-latitude soil of the Arctic. Their structures, including absolute configurations, were authenticated on the basis of the mass spectroscopy (MS), nuclear magnetic resonance (NMR), X-ray crystallography, and electronic circular dichroism (ECD) analysis. The immunosuppressive effects of eutypenoids A–C (1–3) were studied using a ConA-induced splenocyte proliferation model, which suggested that 2 exhibited potent immunosuppressive activities.
Highlights
Marine-sourced fungi are, increasingly, a rich source of novel and bioactive compounds [1,2,3], but natural products from Arctic fungi are rarely studied
C20 determined on theofbasis of the high-resolution electron
Spectra to one carbonyl carbon,carbon, ten olefinic were assigned by distortionless enhancement by polarization transfer (DEPT) and heteronuclear occupied six degrees of unsaturation
Summary
Marine-sourced fungi are, increasingly, a rich source of novel and bioactive compounds [1,2,3], but natural products from Arctic fungi are rarely studied. No such study has been carried out on Eutypella species from the Polar region. D-1, we reported the isolation, structure elucidation, and immunosuppressive effects of three novel. Mar. Drugs 2016, 14, x pimarane diterpenoids (1–3) (Figure 1), each of which possesses a novel structure type of diterpenoid, structure type of diterpenoid, respectively. Drugs 2016, 14, x pimarane diterpenoids (1–3) (Figure 1), each of which possesses a novel structure type of diterpenoid, structure type of diterpenoid, respectively These compounds were evaluated for their immunosuppressive effects
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