Abstract
Differential scanning calorimetry was utilized in the preformulation screening of three multicomponent drug systems at subzero temperatures. The results were demonstrated to be directly comparable to those from differential thermal analysis. The effects of formulation additives on differences in melting behavior and eutectic temperature were investigated. The effect of added sodium chloride varied widely, depending on the nature of the other components. Melting point-composition diagrams were constructed, and percent melt values at a given temperature were calculated. Both eutectic temperature and percent melt values were important to the evaluation of various compositions. Finally, controlled lyophilizations were investigated in an attempt to relate percent melt and final product physical appearance.
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