Abstract
Authors present two cases of dilatory Eustachian tube dysfunction caused by localized nasopharyngeal amyloidosis.
Highlights
A small number of cases of localized amyloidosis of the upper aerodigestive tract have been reported in the literature
In systemic AL amyloidosis, the defective bone marrow plasma cells produce monoclonal antibodies, which lead to amyloid deposits causing damage in multiple organs
Dilatory tube dysfunction can be caused by intrinsic factors, e.g., an acute or chronic mucosal swelling in the nasopharynx, pharyngeal Eustachian tube orifice and mucosa due to an allergic reaction, gastroesophageal reflux disease, and chronic inflammation [9]
Summary
Amyloidosis refers to an extremely rare group of disorders caused by extracellular deposition of abnormal fibrillary proteins (β-fibrils) This condition can either occur locally or systemically. We report two cases of localized AL amyloidosis with nasopharyngeal deposits in the Eustachian tube, resulting in tube dysfunction that presented in our ENT department over the last two years. The first patient (female, Caucasian, 46-year-old) presented with an acute hearing loss and sensation of pressure in both ears for 7 consecutive years She had already undergone repeated T-tube insertions resulting only in a temporary clinical improvement. The second patient (female, Caucasian, 52-year-old) was first diagnosed with nasopharyngeal amyloidosis in 1989 At that time she presented with recurrent middle ear effusion of the left ear. After a 2-month interval of symptom relief, both patients showed recurrent symptoms of middle ear effusion and chronic otitis media in the follow-up
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Archives of Otorhinolaryngology-Head & Neck Surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
