Abstract
GI stromal tumors (GIST) are mesenchymal tumors that express the c-kit proto-oncogen protein. A GIST most often is found in the stomach and endoscopically appears as a smooth subepithelial mass, occasionally with a central erosion or umbilication. The endoscopic appearance may suggest the presence of a GIST, but it is not diagnostic. However, a definitive diagnosis can be made from an EUS-guided biopsy. Endosonographically, GISTs arise from the fourth sonographic (hypoechoic) layer of the gut wall layer, which corresponds to the muscularis propria, or, rarely, from the muscularis mucosa.
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