Abstract
Euryops arabicus Steud (E. arabicus) belongs to the family Asteraceae. It has several uses in folk medicine in the Arabian Peninsula. The current study aimed at evaluating the wound healing properties of the E. arabicus extract in rats. Primarily, E. arabicus successfully accelerated cell migration in vitro and it also showed no signs of dermal toxicity. Topical application of E. arabicus extract (5% or 20%) expedited healing of excised skin in rats. Histological examinations indicated that E. arabicus shortened epithelization period, stimulated fibroblast activity, and increased collagen deposition in wound tissues. The plant extract exerted antioxidant activity as evidenced by inhibition of GSH depletion and MDA accumulation and enhanced mRNA expression of Sod1 in wound tissues collected at the end of the experiment. Further, E. arabicus inhibited the rise of TNF-α and IL-1β in the skin wound region. The anti-inflammatory was confirmed by the observed down regulation of Ptgs2, Nos2, IL-6, and NF-κB mRNA expression. In addition, the extract enhanced the expression of TGF-β1 and HIF-1α in wounded skin tissues as indicated immunohistochemically. Conclusively, E. arabicus expedites excision wound healing in rats. Collagen-enhancing, anti-inflammatory, and antioxidant properties mediate the observed wound healing activity. These findings might contribute to our understanding of the ethnobotanical use of E. arabicus in wounds.
Highlights
Wound is an outcome of physical trauma, which results from any agent that causes cutting, puncture, or contusion in the skin
The plant extract exerted antioxidant activity as evidenced by inhibition of GSH depletion and MDA accumulation and enhanced mRNA expression of Sod1 in wound tissues collected at the end of the experiment
E. arabicus (5% or 20%) significantly enhanced mRNA expression of Sod1, by almost 3.8-fold increase as the untreated control group (Figure 5(c))
Summary
Wound is an outcome of physical trauma, which results from any agent that causes cutting, puncture, or contusion in the skin. The skin has two main layers: epidermis and dermis. Wound healing is a complex process of Oxidative Medicine and Cellular Longevity repairing the damaged tissues. It includes several phases: hemostasis, inflammation, epithelialization, and maturation [3]. Delayed closure of a wound has a significant influence on the quality of patients' life. It leads to loss of function and mobility; anxiety, distress, and social withdrawal; extended hospital stays; and chronic morbidity [4,5,6,7]. Wound dressings'materials have witnessed continuous advancements and improvements [8]
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