Abstract
The occurrence of severe skin burns may lead to delayed wound healing and persistent scarring. Agents that promote angiogenesis hold great promise for enhancing the effectiveness of wound healing, while modulation of oxidative stress, inflammation, and anti-fibrotic cytokines exhibits significant potential in alleviating scars. In this study, a novel hyaluronic acid- chitooligosaccharides/europium (HA-CE) sponge was prepared. HA-CE sponge were highly absorbent and could scavenge free radicals, as well as promoted macrophages polarized toward M2. HA-CE sponge also promoted the angiogenesis, which was related to the increased vascular endothelial growth factor (VEGF) expression. The expression of CD26 in fibroblast was down-regulated and the transforming growth factor-β3 (TGF-β3) was elevated by HA-CE sponge. The HA-CE sponge in the burnt wound model enhanced angiogenesis and anti-inflammatory responses, thereby accelerating healing of burnt wounds and ameliorating scarring-related factors to inhibit scar formation. These findings identified HA-CE sponge had potential to be developed as a dressing for burnt skin wound.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
