Abstract
European Physiome activity is currently funded under the 7th Framework Program VPH call (Virtual Physiological Human), which supports more than a dozen targeted projects and also one Network of Excellence (NoE), whose mission is to coordinate these efforts, explore training possibilities, disseminate information about VPH resources and projects, and furnish a VPH ToolKit. I briefly summarize this activity and then focus on progress in the Renal Physiome, which is linked to the VPH NoE through the SAPHIR Exemplar Project treating blood pressure regulation in a Guyton‐inspired modular modeling environment. The Renal Physiome includes: (1) the Quantitative Kidney DataBase (QKDB) of experimental measurements and anatomical details, (2) links to other disciplines (incl. high‐throughput data) through common ontologies (e.g., FMA, GO...), (3) a library for models of channels and transporters expressed along the nephron, and (4) a repository of legacy models of kidney physiology at various scales (tubule transport, tubuloglomerular feedback, medullary models addressing the problem of urine concentration, etc.), with internet access through a KidneyGrid Portal (in collaboration with Univ. Melbourne).
Published Version
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