Abstract

European sudden cardiac arrest network: towards prevention, education, and new effective treatments ESCAPE NET aims to discover inherited, acquired and environmental causes of sudden cardiac arrest (SCA) and to improve resuscitation treatment for SCA. A shared database of less than 100,000 SCA patients has been created and more than 10,000 DNA samples collected, with procedures for data access by researchers outside the project consortium. ESCAPE-NET has generated 90 peer-reviewed scientific papers.

Highlights

  • The ESCAPE-NET consortium members have recognised the need to maintain this momentum

  • In our search for novel biomarkers, we focused on glycated haemoglobin (HbA1c) levels in the blood—that reflect an individual’s average blood glucose levels over weeks and that is used to monitor the quality of diabetes treatment in patients with diabetes— because this biomarker is known to be associated with various cardiovascular outcomes in persons with diabetes and those without

  • Utilising the large datasets of Sudden cardiac arrest (SCA) victims in the ESCAPENET project and our ability to link them to datasets of clinical care provided by general practitioners and hospitals, we discovered that SCA does not strike unheralded in everone as previously believed (Zylyftari et al, 2021)

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Summary

Warning symptoms before SCA

It is generally acknowledged that SCA strikes unexpectedly in the vast majority of patients. The number of contacts with these health care providers of patients who suffered SCA nearly doubled in the six months leading up to the SCA event, with more than half of patients having health care contacts within two weeks before SCA. This suggests that we may have the opportunity to design strategies to prevent SCA if we are able to recognise the warning signs of impending SCA during these healthcare contacts

Medications may contribute importantly to the occurrence of SCA if they
Women have lower chances to survive SCA
The effects of socioeconomic position on the chances to survive SCA
Summary
PROJECT SUMMARY
PROJECT PARTNERS
Findings
PROJECT LEAD PROFILE
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