Abstract
The European Society of Intensive Care Medicine Annual Congress offers the opportunity for basic scientists and clinicians to share recent findings. Apart from the large number of free communications, several sessions of the congress were dedicated to state-of-the-art tutorials given by established speakers. The areas of interest of the attendees were widely distributed as usual, a reflection of the large array of so-called 'critical illnesses'. The results of clinical trials and experimental findings using recently developed drugs were presented, essentially in the fields of inflammation, sepsis, and acute lung injury. The benefits of several new compounds observed experimentally need to be confirmed clinically. The European Society of Intensive Care Medicine Congress is well established as a unique opportunity to implement and to promote a collaboration between European basic scientists and clinicians.
Highlights
Nitric oxide pathway inhibitorsThe role of nitric oxide (NO) in the cellular alterations of septic shock is intensively investigated
The European Society of Intensive Care Medicine Congress is well established as a unique opportunity to implement and to promote a collaboration between European basic scientists and clinicians
The Annual Congress of the European Society of Intensive Care Medicine (ESICM) gathered 2500 registered participants, mainly physicians, nurses and physiotherapists working in the intensive care unit (ICU)
Summary
The role of nitric oxide (NO) in the cellular alterations of septic shock is intensively investigated. Dr Siegemund et al, from the University of Basel, Switzerland, found that 1400W inhibitor restored gut perfusion, decreased functional oxygen shunting, and increased coronary blood flow and myocardial microvascular oxygenation in a porcine model of endotoxemia. Dr Kollef et al of Washington University School of Medicine, Missouri, USA, found that the topical oral administration of Iseganan, a synthetic analog of the protegrin antimicrobial peptides, decreased the oral microbial burden of intubated patients. Promising, this approach warrants confirmation in large-scale studies
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