Abstract
A retrospective EMSOS study to assess risk factors for local recurrence in desmoid tumors was initiated in 1991. Paticnts and methods. 1.51 patients treated at 1 1 EMSOS institutions were studied. The average age was 33 (1-80) years and 82 were women Tumor locations were: upper extremity 39, lower extremity 40, trunk 49, neck 5 , other sites 13, and multiple sites 5. The average tumor size was 7 (1340) cm. 145 patients were operated on. 2 patients received preand 6 patients postoperative radiotherapy. 5 patients received medical treatment ( 1 tamoxifen, 4 chemotherapy). Histopathology review, DNA-cytometry, proliferating cell nuclear antigen (PCNA) and estrogen receptor determination were performed. Re.sdt.s. The diagnosis was confirmed in all cases. All primary tumors were diploid and estrogen receptor negative. A Cox regression analysis showed a 4.0 relative risk for upper extremity location and a 2.5 relative risk for marginal excision, respectively, for occurrence of first local recurrence. Tumor depth, vascular pattern, cellularity and PCNA index were of no prognostic importance.
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