Abstract
BackgroundTo guide decision-making on immunisation programmes for ageing adults in Europe, one of the aims of the Vaccines and InfecTious diseases in the Ageing popuLation (IMI2-VITAL) project is to assess the burden of disease (BoD) of (potentially) vaccine-preventable diseases ((P)VPD). We aimed to identify the available data sources to calculate the BoD of (P)VPD in participating VITAL countries and to pinpoint data gaps. Based on epidemiological criteria and vaccine availability, we prioritized (P) VPD caused by Extra-intestinal pathogenic Escherichia coli (ExPEC), norovirus, respiratory syncytial virus, Staphylococcus aureus, and pneumococcal pneumonia.MethodsWe conducted a survey on available data (e.g. incidence, mortality, disability-adjusted life years (DALY), quality-adjusted life years (QALY), sequelae, antimicrobial resistance (AMR), etc.) among national experts from European countries, and carried out five pathogen-specific literature reviews by searching MEDLINE for peer-reviewed publications published between 2009 and 2019.ResultsMorbidity and mortality data were generally available for all five diseases, while summary BoD estimates were mostly lacking. Available data were not always stratified by age and risk group, which is especially important when calculating BoD for ageing adults. AMR data were available in several countries for S. aureus and ExPEC.ConclusionThis study provides an exhaustive overview of the available data sources and data gaps for the estimation of BoD of five (P) VPD in ageing adults in the EU/EAA, which is useful to guide pathogen-specific BoD studies and contribute to calculation of (P)VPDs BoD.
Highlights
To guide decision-making on immunisation programmes for ageing adults in Europe, one of the aims of the Vaccines and InfecTious diseases in the Ageing popuLation (IMI2-VITAL) project is to assess the burden of disease (BoD) of vaccine-preventable diseases ((P)VPD)
This resulted in a list of seven infectious diseases: influenza, varicella/herpes zoster, herpes simplex virus, norovirus, respiratory syncytial virus (RSV), Staphylococcus aureus (S. aureus), extra-intestinal pathogenic Escherichia coli (ExPEC), and pneumococcal pneumonia (PnPn)
The experts were identified by the IMI2-VITAL partners who aimed to adhere to the European Centre for Disease Prevention and Control (ECDC) national focal points
Summary
To guide decision-making on immunisation programmes for ageing adults in Europe, one of the aims of the Vaccines and InfecTious diseases in the Ageing popuLation (IMI2-VITAL) project is to assess the burden of disease (BoD) of (potentially) vaccine-preventable diseases ((P)VPD). To guide decision-making about potential prevention strategies for this age-group, it is essential to understand the burden of disease (BoD) and to identify existing data gaps. In this context, the second Innovative Medicine Initiative (IMI2) supported the Vaccines and InfecTious Diseases in the Ageing PopuLation (IMI2-VITAL) project [15], which aims to address the current challenges of (potentially) vaccine-preventable diseases ((P)VPD) in ageing adults in the EU/EEA. The project will provide evidence-based knowledge on possible specific vaccination strategies to enhance healthy ageing
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