Abstract
Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (1–4) as well as previously reported metabolites (5–13) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC50 = 3.3 µM). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra.
Highlights
The genus Euphorbia is the largest genus in the family Euphorbiaceae
A methylene chloride/methanol (1:1) extract of air-dried, aerial parts of E. sanctae-catharinae was separated into pure chemical components using normal and reversed phase chromatographic was separated into pure chemical components using normal and reversed phase chromatographic separations to afford new (1–4)
For all naturally derived myrsinol diterpenes isolated to date, the three (5/7/6) fused ring system that forms the derived myrsinol diterpenes isolated to date, the three (5/7/6) fused ring system that forms the myrsinol skeleton are joined in a trans configuration with H-4 and H2-17 α-oriented
Summary
The genus Euphorbia is the largest genus in the family Euphorbiaceae. The genus comprises over 2000 species worldwide [1] and its global distribution includes more than 750 species in Africa and 42 indigenous to Egypt [2]. A number of biological activities ranging from cytotoxic [7], hepatoprotective [8,9], antispasmodic [10], anti-inflammatory [11], antibacterial [12,13], antifungal [10]. ( known as St. Katherine spurge) endemic to the Gebel Wadi, a system of deep/dry river antifungal [10] and anti-mutagenic [14], antiviral [15] have been reported. As partsecondary of our research to investigate and investigation of E.bysanctae-catharinae that targets metabolites that may exhibit biologically evaluate the wild Egyptian plants [18,19,20,21,22,23,24,25], it is the first phytochemical anti-tumor activity. Investigation of E. sanctae-catharinae that targets secondary metabolites that may exhibit anti-tumor activity
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