Abstract
Four new tetracyclic triterpenoids (1–4) were isolated from the leaves and twigs of Jatropha gossypiifolia. Their structures were elucidated by MS and NMR data analysis, together with the Mo2(OAc)4-induced CD data. Jagabeoeuphols A-C (1–3) are rare 19(10 → 9)abeo-euphane-type triterpenoids possessing a Δ5(10) group and a 7,8-epoxide moiety, and jagoseuphone A (4) is a typical euphane-type triterpenoid. The inhibitory effects of 1–4 on nitric oxide production induced by lipopolysaccharide in RAW264.7 cells were evaluated, and 4 exhibited moderate inhibitory activity with an IC50 value of 20.1 μM.
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