Abstract
Eugenol inhibits veratridine-induced non-convulsive seizures and wet dog shakes via blockage of sodium and calcium influx in rat cerebrocortical synaptosomes
Highlights
Epilepsy is a chronic neurological condition which affects roughly 50 million people worldwide (Fiest et al, 2017)
Studies have confirmed that the electroencephalogram (EEG) pattern produced by veratridine (VTD) administration is comparable to that seen in absence seizures, partial seizures, and epileptic encephalopathies
Animals were observed for seizure activity and the number of wet dog shakes (WDS)
Summary
Epilepsy is a chronic neurological condition which affects roughly 50 million people worldwide (Fiest et al, 2017). Epilepsy is a major concern for public health given its significant impact on the physical, social, cultural, and economic aspects of an individual. The quest to identify potential, novel therapeutic agents for the management of epilepsy necessitates the use of seizure models. Veratridine (VTD) is a nonselective activator of voltagegated sodium channels and calcium channels (Weuring et al, 2020; Zhang et al, 2017). It has been used in various in vitro and in vivo models and has shown to possess seizure-inducing
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