Abstract

Various Grignard reagents, derived from bromopyridine, furan, thiophene and selenophene have been synthesized via an exchange reaction between heterocyclic bromides and isopropylmagnesium chloride. The NMR parameters were determined and related to the electronic structure; an “ ortho effect” is evidenced in the pyridine derivatives but is not apparent in the pentagonal heterocycles. The exchange mechanisms were studied and the activation functions were evaluated for the rate-determining step of the formation and for the Schlenk equilibrium.

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