Etude in vitro des propriétés anti-inflammatoires de l’extrait méthanolique des fruits de Rosa canina L. (Rosacées)

Abstract

Introduction. Medicinal plants are considered an inexhaustible source of bioactive compounds such as phenolic compounds. Rosa canina L. (Rosaceae) known as Thebgha in Eastern Algeria, is widely used in traditional medicine, and nutrition. Objective. The aim of this study was to assess the anti-inflammatory activity of methanolic fruit extract from the medicinal plant R.canina. Material and methods. This study on R.canina focused on phytochemical screening. Determination of total phenolic compounds content by the fast blue BB test (FBBB), and evaluation of in vitro anti-inflammatory power by colorimetric methods relating to the denaturation of bovine serum albumin (BSA) and egg albumin were essayed. Results. The methanolic extract was prepared by the use of solvents with increasing polarity. The extract of R.canina fruits was rich in polyphenols. Concerning the anti-denaturation activity, the methanolic extract showed a high percentage of BSA inhibition of 89.34%, and egg albumin of 93.41% at the highest concentration. Thus, our results indicated that the extract had a significantly good anti-denaturation activity, compared to diclofenac. Conclusion. Our study show clearly that the methanolic extract of the R. canina fruits has a significant anti-denaturing property.