Abstract
Erucic acid (22:1) metabolism was studied in human and in rats. We explored, in seven subjects, the myocardial extraction of free erucic acid, 3 h after a rapeseed oil meal; we concluded that 22:1 is extracted as other fatty acids, but oleic acid (18:1). Rat tissues Jipoprotein lipase activity was measured; it appeared that heart muscle and epididymal fat pad preparation of lipoprotein lipase liberate similarly erucic acid from chylomicrons. Then, during triérucine administration in rats, we examined the fatty acid content of triglycerides from heart, kidneys and adipose tissue; we found a tremendous accumulation of 22:1 in heart muscle in comparison with kidney. This fact is related to a slow catabolism of 22:1 in myocardium; on these results, an extra-mitochondrial oxidation of 22:1 to lower fatty acids and the secundary enzymatic adaptation of heart are discussed.
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