Etude du coefficient d’épuration lipidique K<sub>2</sub> chez les sujets atteints d’hyperlipoprotéinémie de type IV avant et après réduction de l’hypertriglycéridémie par un traitement diététique adapté

Abstract

An intravenous fat tolerance test (IV FTT) was performed in a group of patients with type IV hyperlipoproteinemia before and after reduction of triglyceride level, the latter is obtained through a diet adapted to the nutritional sensitivity, body weight remaining constant. Before the diet the increase in cholesterol (CT) and triglycerides (TG) was related in both obese and non-obese patients to an increase in very-low-density lipoproteins (VLDL), while other lipoprotein fractions were not affected. In these patients, K<sub>2</sub> is significantly lower than in controls whatever the nutritional sensitivity. However, K<sub>2</sub> is lower in obese patients than in patients with normal weight, VLDL-CT and VLDL-TG are tremendously reduced by the relevant diet and K<sub>2</sub> is constantly and significantly increased, although it does not reach a normal value in obese subjects. There is a highly significant correlation between VLDL-TG levels and K<sub>2</sub> in obese and non-obese subjects. Several physiopathological explanations are discussed to account for the variation of K<sub>2</sub> according to TG levels. The results obtained support the view that the K<sub>2</sub> defect is secondary to the hyperlipoproteinemia.