Abstract

Etrasimod (APD334) is a selective sphingosine 1-phosphate receptor 1,4,5 (S1P1,4,5) modulator in development for atopic dermatitis (AD). S1P1 modulates trafficking of many immune cells, including those in eczematous skin. This study evaluated the effect of etrasimod on circulating and tissue immune cells and its impact on skin inflammation in a dermatitis mouse model. BALB/c mice

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