Etiopathogenetic neuroreparative therapy of encephalopathies

Abstract

The possibility of neural tissue regeneration in encephalopathies of various genesis by influencing brain cell pool with reduced functional activity in the state of parabiosis is discussed. The use of a neuroprotective agent rekognan (citicoline) is a justified etiopathogenetic therapy realizing its effects through mechanisms of synthesis of membrane phospholipids, inhibition of synthesis of phospholipase A2, restoration of Na+/K+-adenosine triphosphate functioning, blocking of oxidative stress and apoptosis, modulation of choline, dopamine and glutamatergic neurotransmission. Electroencephalography study was made in order to investigate reactivity of a brain in 12 patients (6 men and 6 women, average age 57±11 years) with encephalopathies to treatment with the Rekognan. The relative index - K α/θ spectra of electroencephalogram power - was used to assess the dynamics of the functional state of a brain before and after the course of treatment with a neuroprotective agent. The majority of patients (9 patients) had a statistically significant positive electrophysiological dynamics with an average increase of K α/θ by 64%. Deprivation of the focus of irrigation in the form of a «running» of reduced acute waves in the right temporal region was recorded in one case, revealed during the test with hyperventilation. An additional prescription for the main therapy of the course of the recognan is associated with an increase in the power of electroencephalogram spectra in a frequency of the dominant alpha rhythm in 75% of patients with encephalopathies of different etiology. Favorable dynamics K α/θ spectra of electroencephalogram power testifies to the involvement of the cerebral reserve due to the neuroreparative effect of recognan.