ETIOPATHOGENESIS AND CLINICAL-MORPHOLOGICAL ASPECTS OF MENINGIOMAS. ASSESSMENT OF INDICA- TORS OF MORBIDITY

Abstract

Meningiomas make up a third of all CNS tumors. Despite this, the issues of their therapeutic treatment, clinical course, histological structure, etiology and risk factors remain poorly understood. In comparison, for example, with gliomas. In part, this may be due to the fact that 90% of diagnosed meningiomas are benign and have a small number of genomic aberrations. Unfortunately, a limited number of cancer registries register only malignant neoplasms. Available global annual incidence rates, standardized by gender and age, range from 2/100 000 to 8/100 000 cases. Over the past decade, the incidence of meningiomas in different countries has increased. It has been suggested that the increase in incidence is associated with an aging population. Although these factors are important, they cannot explain the increase in the incidence rate in most age groups. We carried out a clinical and morphological study of meningiomas, a total of 72 cases, with a study of the frequency of occurrence of various species in different age groups and gender. Among the sample, the incidence of meningiomas in women was 74% versus 26% in men. The number of diagnosed meningiomas in men increases linearly from younger age groups to older groups. In women, the frequency of occurrence of meningiomas is distributed unimodally with the largest number of diagnosed meningiomas in the range from 45 to 59 years. To date, it has been proven that the development factors are meningiomatic genetic diseases (type 2 NF2- neurofibromatosis) and ionizing radiation. Among other reasons - the development of endogenous factors, an imbalance of sex hormones. An imbalance of female sex hormones is likely to be involved in oncogenesis in women, especially in the postmenapausal period.