Abstract
Background: Neonatal seizure is a rare neurologic condition. The current study aimed at determining the etiology of neonatal seizure. Methods: The current study evaluated the data of 100 neonates who were hospitalized at neonatal intensive care unit (NICU) during 2015-2017. A pediatric neurologist made the final diagnosis of seizure. Patients’ medical records were used to review neonatal seizure variables. SPSS (version 16) was used to perform the statistical analyses. Results: The current study enrolled 100 newborns (41% female) admitted to the NICU following the first episode of seizure and the body temperature of 36.8-39.2°C (mean: 37.2°C). Of 100 participants, 94 (94%) had acute symptomatic seizure and 6 (6%) were compatible with neonatal epilepsy syndrome criteria. According to the results, the commonest etiologies were the neonatal encephalopathy and hypoxic-ischemic encephalopathy constituting 82% of participants. Conclusion: The consequences of acute symptomatic seizures in neonates are determined mainly by the etiology of the seizures. Seizure burden and use of anti-seizure drugs may also have some impact, but this has yet to be fully defined.
Highlights
To manage neonatal seizure, clinical objectives should primarily be considered as the etiology of seizure
In the current study 100 newborns experiencing the first episode of seizure admitted to the neonatal intensive care unit (NICU) were enrolled (41% female)
The present hospital-based, cross sectional study performed on newborns admitted to NICU following an acute episode of seizure aimed at determining the etiology and gender-specific pattern of seizure in the selected subjects
Summary
Clinical objectives should primarily be considered as the etiology of seizure. An untreated underlying cause of seizure may lead to CNS disease, while treatments designed based on etiology of the disease can be administered following a timely detection. Several causes were identified for seizure; but a pathway of abnormal neural discharge is proven. The current study aimed at determining the etiology of neonatal seizure. Results: The current study enrolled 100 newborns (41% female) admitted to the NICU following the first episode of seizure and the body temperature of 36.8-39.2°C (mean: 37.2°C). Of 100 participants, 94 (94%) had acute symptomatic seizure and 6 (6%) were compatible with neonatal epilepsy syndrome criteria. Conclusion: The consequences of acute symptomatic seizures in neonates are determined mainly by the etiology of the seizures.
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