Abstract
Drug induced liver injury (DILI) is one of the common cause of liver toxicity. Most of the drugs used today are hepatotoxic. DILI accounts for approximately one-half of the cases of acute liver failure and mimics all forms of acute and chronic liver disease. It is the single most common adverse drug reaction leading to a halt in the development of new medication by pharmaceutical company, failure of new drug to obtain regulatory approval, and withdrawal or restriction of existing drug from the market. The aim of this study is to evaluate common causes and patterns of DILI in our setting. Twenty-seven patients were enrolled in the study. Ant tubercular drugs were most common cause of DILI, accounting for 48.2%. Other common causes of DILI were paracetamol (14.8%) and NSAID’s (11.1%). The most common pattern of liver injury seen was mixed pattern which was present in63%, followed by cholestatic and hepatocellular pattern. Hence, we should be very careful while prescribing these frequently used drugs.
Highlights
Drug induced liver injury (DILI) is one of the common cause of liver toxicity
As liver is responsible for concentrating and metabolizing a majority of medications, it is a prime target for medicationinduced damage. It is a common cause of acute liver failure, accounting for 13% in the United States.[2]. It is the single most common adverse drug reaction leading to a halt in the development of new medications by pharmaceutical companies, failure of new drugs to obtain regulatory approval and withdrawal or restriction of existing drugs from the market.[3,4,5]
All patients who present with signs and symptoms of liver toxicity and deranged liver function test according to INDILI criteria, after ingestion of any drug at least for 5 days were included in the study
Summary
Drug induced liver injury (DILI) is one of the common cause of liver toxicity. Most of drugs used today are hepatotoxic. It accounts for approximately one-half of the cases of acute liver failure and mimics all forms of acute and chronic liver disease.[1] As liver is responsible for concentrating and metabolizing a majority of medications, it is a prime target for medicationinduced damage. It is the single most common adverse drug reaction leading to a halt in the development of new medications by pharmaceutical companies, failure of new drugs to obtain regulatory approval and withdrawal or restriction of existing drugs from the market.[3,4,5] Its annual incidence in general population ranges from 14 to 19 per 100,000 inhabitants, with approximately 30% exhibiting jaundice.[6,7] Overall mortality from 10 to 17.3% has been observed in several series.[8,9,10,11]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
