Abstract
Neonatal lupus syndromes (NLS) is an acquired autoimmune disease, which is mediated by maternal antibodies. Maternal anti-Sjogren′s syndrome A (SSA)/Ro, and anti-Sjogren′s syndrome B (SSB)/La antibodies are related with the transient cutaneous lupus and (or) transient/permanent congenital heart block (CHB). Though NLS is rare, it is seriously harmful to children or fetuses with CHB. There are many studies on the etiology and pathogenic mechanism of NLS, but the specific factors leading to the occurrence and development of NLS are still unclear. This article focuses on the current researches on etiology and pathogenesis of NLS and provides references for clinical treatment and further research of NLS. Key words: Lupus erythematosus, cutaneous; Heart block; Atrioventricular block; Sjogren′s syndrome; Neonatal lupus syndromes; Anti-Sjogren′s syndrome A antibody; Anti-Sjogren′s syndrome B antibody; Infant, newborn
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have