Etiology analysis of 86 children with end-stage renal disease in a single-center

Abstract

Objective To investigate the etiology composition of end-stage renal disease (ESRD) in children, in order to provide reference for the prevention and treatment. Methods The children with ESRD who were diagnosed in Peking University First Hospital from January 2005 to October 2013 were selected, and the etiology composition and incidence of the children with ESRD were retrospectively analyzed.Diagnostic criteria for children with ESRD refer to the clinical practice guidelines for chronic renal disease(NKF/KDOQI), developed by the American kidney foundation in 2002. Results Eighty-six children with ERSD were enrolled including 53 cases of males, 33 cases of females, with the male to female ratio of 1.61∶1.00 and the mean onset age was (7.08±4.23)years old, and their average diagnosis age was(9.25±4.17)years old.The median duration of ERSD before diagnosis was 0.84(0.01-13.67)years.The main cause of ESRD was acquired renal disease, accounting for 43.02%(37/86 cases), mainly the chronic glomerulonephritis (18/86 cases, 20.93%) and nephrotic syndrome (16/86 cases, 18.60%); followed by urinary congenital abnormity, accounting for 40.70%(35/86 cases), in which the most common were renal dysplasia (18/86 cases, 20.93%) and cystic renal disease (11/86 cases, 12.79%). Children under 3 years old mainly showed congenital urinary tract abnormalities(6/10 cases, 60.00%). But children over 3 years old mainly showed acquired renal diseases(37/76 cases, 48.7%), and pathologic classification of glomerular disease were proliferative mesangial glomerulonephritis (6/23 cases, 26.09%), focal segmental glomerulosclerosis (5/23 cases, 21.74%) and interstitial nephritis(3/23 cases, 13.04%). Conclusions The main etiology of ESRD is glomerular disease and congenital abnormal development of urinary system, therefore, more attention should be paid on the ultrasound screening of the urinary tract in the perinatal period and urine screening in children.There are great significances in reducing the incidence of ESRD and intervening actively the progression to chronic kidney disease. Key words: End-stage renal disease; Etiology; Child