Etiological study of acute retinal necrosis

Abstract

Objective To investigate the importance of etiological research in clinical therapy of acute retinal necrosis (ARN) . Methods Retrospective cases-series study. Analyzed the clinical data of 45 eyes (39 cases) of ARN patients who were diagnosised in the Department of Ophthalmology of PUMCH during January 1996 to December 2012. All patients underwent routine eye examination. Blood samples were taken from 39 patients for serum TORCH test, 22 patients underwent total serum IgG detection. 15 eyes underwent the TORCH and total IgG detection of vitreous humor. The control group: 15 patients (15 eyes) underwent vitrectomy surgery for non-infectious retinal disease during June 2006 to November 2008 in PUMCH. During the process of operation, venous blood and vitreous humor was drawn for the total IgG and the TORCH test respectively. Data were analyzed using independent t test. Results The total IgG results of control group patients' was 10.02±2.69 g/L, and was 10.10±2.38 g/L in ARN group. The difference was not statistically significant. The Vitreous humor total IgG of control group was 135.3±178.0 mg/L. HSV-IgG and CMV-IgG was detected in the vitreous humor of 15 eyes, the average value of the total IgG of vitreous humor was 2 949.2±1 845.1 mg/L. The difference between vitreous humor total IgG was statistically significant (t=6.024, P 6, the value suggested the pathogens was HSV. Conclusion The pathogens were suggested by the detection of specific antibodies to the virus in vitreous humor. The treatment for the cause can improve the therapy of ARN. Key words: Retinal necrosis syndrome, acute; Laboratory technigues and procedures; Titers; Goldmann-Witmer C