Etiological analysis of virus in children with respiratory tract infection during spring in Shenyang regions

Abstract

Objective To investigate the distribution of respiratory viruses in the throat swabs from children with respiratory tract infection in Shenyang and provide reference for the diagnosis and treatment of clinical diseases. Methods A total of 756 children with respiratory tract infection who were admitted to Shengjing Hospital of China Medical University in Shenyang from February 2018 to May 2018 were enrolled in this study.The antigens of influenza virus A (INF-A), influenza virus B (INF-B), adenovirus (ADV), respiratory syncytial virus (RSV), and parainfluenza virus types I, Ⅱ, and Ⅲ (PIV-Ⅰ, PIV-Ⅱ and PIV-Ⅲ) in nasopharyngeal swabs were detected by direct immunofluorescence. Results Of all the 756 throat swabs from hospitalized children, 214 (28.31%) had positive virus detection results.RSV (11.38%) had the highest detection rate in single-positive cases, accounting for 47.78% of single positive cases.In mixed virus infection, RSV combined with other viral infections accounted for 73.53% of mixed virus infections, and RSV was the main pathogen found in the study population.Analysis of the detection rate of virus infection related with age and gender showed that the younger the age, the higher the detection rate(χ2=14.216, P=0.007). The detection rate of patients younger than 6 months was 39.73% and RSV was the mostly detected pathogen (75.86%). The detection rate of male patients was 30.07%, which was higher than that of female patients with 25.99%(χ2=3.982, P=0.046), and RSV infection and mixed infection were the major.There was no significant difference in virus detection rates between patients with different clinical diagnoses. Conclusion RSV is the main pathogen during spring from February 2018 to May 2018 in Shenyang.The virus detection rate of patients younger than 6 months is higher and RSV is the mostly detected pathogen. Key words: Respiratory virus; Antigen; Direct immunofluorescence; Children