Etiological analysis of febrile respiratory syndrome in southwest region of China

Abstract

Objective To understand the distribution and epidemiological characteristics of pathogens for febrile respiratory syndrome in southwest region of China. Methods From Jan 12, 2012 to March 14, 2015, samples and information of 10 384 patients were collected from five provinces in southwest region of China, including Yunnan, Sichuan, Chongqing, Tibet and Guizhou, through Pathogens Surveillance Platform for Febrile Respiratory Syndrome of National 12th Five Year Major Project. Influenza virus (Flu), respiratory syncytial viruses (RSV), human para-influenza viruses (HPIV), human adenovirus (ADV), human coronavirus (HCoV), human metapneumovirus (HMPV), human boca virus (HBoV) and human rhinovirus (HRV) were tested, and the positive rates of different viruses were characterized. Results From 10 384 surveillance cases, 8 013 samples were tested, and the positive rate of all viruses was 33.31% (2 669 cases). The positive rate of HRV was the highest (10.23%, 820 cases) and HMPV was the lowest (1.05%, 84). The positive rates of RSV, HRV, HPIV and HBoV in 0-5 years old group were the highest (14.74%, 14.64%, 9.71% and 7.16%, respectively). In addition, the positive rate of HCoV in naopharyngeal swabs was the highest among all samples, accounting for 2.47%. Both positive rates of RSV and HRV were the highest in nasopharyngeal aspirate samples, accounting for 20.28% and 21.74%, respectively. The detection rates of HRV and Flu in Guizhou were rather high, reaching 13.66% and 11.95%, respectively. In Chongqing, positive rate of RSV was the highest, accounting for 16.95%. In Sichuan, the detection rates of HRV and HPIV were the highest, accounting for 13.55% and 9.81%, respectively. More than one virus were detected from 656 samples among all surveillance cases. Infections with two viruses accounted for 83.54% (548 cases) of the multiple infections. Conclusions The pathogens were different in different areas. Detection rate of virus in nasopharyngeal aspirate samples was the highest. So it is very important to strengthen and to improve surveillance platform, so as to provide references for clinical diagnosis, diseases treatment. Key words: Fever; Population surveillance; Viruses; Febrile respiratory syndrome