Etiologic and diagnostic analysis of 270 children with short stature in China Jining region

Abstract

Objective To explore the etiology of two hundred and seventy children with short stature and the diagnostic clue. Methods Two hundred and seventy children of outpatient were collected from April 2013 to April 2014 in the Growth and Development Department of Affiliated Hospital of Jining Medical College.Among them, one hundred and seventy-nine were males (66.30%), ninty-one were females(33.70%). All of the children were collected detail medical history and taken both physical and laboratory examinations. Results There were 18 kinds of causes of short stature in two hundred and seventy children, the top five respectively were: one hundred and fifty cases (55.56%) diagnosed as growth hormone deficiency(GHD), eight-one cases (30.00%) with idiopathic short stature (ISS), eleven cases (2.59%) with hypothyroidism, seven cases(2.59%) with small for gestational age (SGA), seven cases (2.59%) with turner syndrome (TS). In addition, two cases (0.74%) of pituitary stalk interruption, while the neurofibromatosis, familial short stature, constitutional delayed puberty, precocious puberty, rickets, Bartter syndrome, Russell-Silver syndrome, Kallmann syndrome and pituitary space-occupying lesions were each one cases(total 3.33%). There were three cases(1.11%)combined with other chronic diseases.Forty-nine children(18.14%) were under 7 years old.Among them, thirty-seven were males, twevele were females, and the main reason for these children with short stature were GHD, ISS and SGA.One hundred and forty-six children were among 7-13 years old, among them, eighty-two were males, sixty-four were females.seventy-five children were among 13-18 years old, sixty were males, fifteen were females, and the same main etiologies for these two groups were all GHD, ISS and hehypothyroidism disease. Conclusions The etiologies of children with short stature of Shandong Jining region are complex.The clinical manifestations of short stature are different, and the correct diagnosis and appropriate treatment is very important. Key words: Children; Short stature; Diagnosis