Abstract
A comparison of EE-2 concentrations in blood and endometrium of women under sequential therapy (Group I: chlormadinone acetate + mestranol; 2 mg + 80μg, n = 24) and under combined therapy (Group II: norgestrel + EE-2: 0.5 mg + 30μg, n = 23), was performed. By means of reliable radioimmunoassay techniques, simultaneous determinations were made of the synthetic estrogen in both plasma and endometrium covering several days of the pseudomenstrual cycle. The mean ± SD plasma EE-2 concentrations observed for Group I was 1021 ± 140 pg/ml and that for Group II was 83 ± 16pg/ml. while endometrial concentrations (wet tissue) were: 4.7 ± 1.9 μg/g and 89 ± 13 ng/g respectively. The results show: (1) Greater EE-2 concentrations in the endometrium than in plasma, in both groups. (2) The EE-2 concentrates 10 times more in blood and in the order of μg in endometrium of Group I than in Group II. Together with data presented in other papers of this series, these simultaneous studies may permit understanding the role of circulating hormones in local biologic phenomena.
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