Abstract

The following is a brief background and account of the psychostimulant "designer drug" and curious methylphenidate-ethanol transesterification metabolite, ethylphenidate (EPH; Fig 1). That is ethylphenidate with an "E", not it's well known homolog, methylphenidate (MPH; Ritalin, Concerta, others) – the first-line agent for the treatment of attention-deficit/hyperactivity disorder (ADHD). Note that the only structural difference resides in the ester where EPH has an ethyl group rather than the methyl group in MPH.

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