Abstract
Extracts of Radix Cynanchi Auriculati (RCA) have multiple effects. However, it remains unclear whether RCA extracts can exhibit antioxidant activity by regulating MAPKs/Nrf2/HO-1 pathways. In this study, we evaluated the antioxidant activity of ethyl acetate extract of RCA (RCAEA) via LPS-induced RAW264.7 cells, and investigated the potential mechanism of its protective effect against oxidative damage on macrophages. The results showed that RCAEA activating MAPKs/Nrf2/HO-1 pathways. In conclusion, the aim of this study was to describe the molecular mechanisms responsible for the RCAEA mediating the inhibitory effects of oxidative stress in RAW264.7 cells.
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