Abstract
In the structure of the title steroid, C23H34O3, the molecules are linked in infinite chains through intermolecular C11(n) O—H⋯O hydrogen bonds between the hydroxy proton and the ester carbonyl O atom.
Highlights
In the structure of the title steroid, C23H34O3, the molecules are linked in infinite chains through intermolecular C11(n) O— HÁ Á ÁO hydrogen bonds between the hydroxy proton and the ester carbonyl O atom
Our aim is to increase the lipophilicity of the parent drug by attaching a steroid moiety which could have anti-TB activity in its own right
The molecules in the crystal structure are linked through intermolecular C11(n) (Bernstein et al, 1995) O—HÁ Á ÁO hydrogen bonds between the O3 hydroxy proton and the O21 carbonyl O atom (Table 2), forming infinite chains along the body diagonal of the unit cell
Summary
In the structure of the title steroid, C23H34O3, the molecules are linked in infinite chains through intermolecular C11(n) O— HÁ Á ÁO hydrogen bonds between the hydroxy proton and the ester carbonyl O atom. Our aim is to increase the lipophilicity of the parent drug by attaching a steroid moiety which could have anti-TB activity in its own right As part of this project, compound (II) was prepared from the commercially available ketone, dehydroandrosterone (I) (Verma et al, 2004), by the Wittig–Horner reaction (Wicha et al, 1977), and was recrystallized from methanol. The molecules in the crystal structure are linked through intermolecular C11(n) (Bernstein et al, 1995) O—HÁ Á ÁO hydrogen bonds between the O3 hydroxy proton and the O21 carbonyl O atom (Table 2), forming infinite chains along the body diagonal of the unit cell. ESMS (m/z): +ve ion, 381.15 [M + Na]+, 359.13, [M + H]+
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