Abstract
Synthesis of benzalacetophenones (1a-c) has been achieved by the aldol condensation of substituted acetophenone with benzaldehyde. These were treated with thiourea by utilizing HCl to give substituted dihydropyrimidine-thiones (2a-c). Cyclization of these compounds with DMF and chloroacetic acid yielded pyrimidothiazolidinone moieties (3a-c). Reaction of benzaldehyde with 3a-c produced corresponding chalcone derivatives (4a-c). These chalcone derivatives when treated with guanidine nitrate in presence of a base gave (5a-c). Condensation of 5a-c with bromoethoxyphthalimide afforded titled compounds (6a-c). Structures of prepared scaffolds were established by the spectral studies, elemental analysis and chemical tests. Subsequently, heterocyclic hybrids (5a-c, 6a-c) were assayed to their in vitro anti-microbial activity against a variety of infectious strains of bacteria and fungi.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
