Ethosomal drug delivery system: A novel approach to transdermal drug delivery: A review

Abstract

Ethosomes are novel lipid vesicular carriers containing a relatively high percentage of ethanol and the novel approach for the current drug delivery as a transdermal drug delivery system which is employed for the assessment of the targeted drug to the site of action. There are many application in the development of the formulation for the better release to the systemic circulation. The therapeutic effect of these category of formulation totally depends upon the medium of the drug release, in which we can observe the amount of drug in the formulation and drug released to the site of action. Ethosomes are vesicular carrier comprise of hydroalcoholic or hydro/alcoholic/glycolic phospholipid in which the concentration of alcohols or their combination is relatively high. Ethosomes can entrap drug molecule with various physicochemical characteristics i.e. of hydrophilic, lipophilic, or amphiphilic. These formulations are better alternative of oral drug delivery in that patients, those cannot take orally.