Abstract
Most of the cancer chemotherapeutic agents are associated with toxicity towards normal cells and tissues that share many characteristics with tumor cell, and in particular, high cell turnover. Optimal dosing of cancer chemotherapeutic agents is often limited because of severe non-myelosuppressive and myelosuppressive toxicities, therefore it is a continuing challenge to design therapy that is effective and also efficiently targeted towards tumor cells. Cytoprotective agents are expected to control or prevent these toxicities and include the use of synthetic and natural products. Specific chemoprotectants are emerging for cisplatin and anthracyclin antibiotics. None of the available agents satisfy criteria for an ideal chemoprotection. This has stimulated research for discovering natural resources with immunomodulatory and cytoprotective activities. Various botanicals and ethnopharmacological agents used in traditional medicine have been investigated by various workers for their chemoprotective, immunomodulating, adaptogenic and anti-tumor activities and have revealed promises towards developing into a potential drug for cancer treatment per se or as an adjuvant.
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