Abstract
Bridelia micrantha is traditionally used in tropical Africa to treat a wide range of human and animal diseases. The aim of this study was to summarise the research that has been done on the ethnomedicinal uses, phytochemistry and pharmacological properties of B. micrantha so as to understand its importance and potential value in primary healthcare systems. The literature search for information on ethnomedicinal uses and pharmacological activities of B. micrantha was undertaken using databases such as Web of Science, Scopus, Google Scholar, Science Direct, BioMed Central (BMC), PubMed and Springerlink. Other relevant literature sources included books, book chapters, websites, theses, conference papers and other scientific publications. This study showed that B. micrantha is used as herbal medicine in just over half (57.3%) of the countries in tropical Africa where it is indigenous. A total of 54 ethnomedicinal uses of B. micrantha have been recorded with a high degree of consensus on burns, wounds, conjunctivitis, painful eyes, constipation, gastric ulcers, cough, headache, rheumatism, painful joints, dysentery, ethnoveterinary medicine, malaria, sexually transmitted infections, stomach ache, tape worms and diarrhoea. Different plant parts, aqueous and organic extracts exhibited anthelmintic, antimicrobial, anticonvulsant and sedative, antidiabetic, antidiarrhoeal, antinociceptive, antioxidant, antiplasmodial, antischistosomal, hepatoprotective, insecticidal and β-lactamase inhibitory activities.
Highlights
IntroductionBridelia micrantha (Hochst.) Baill. is a small to medium sized tree belonging to the family
Bridelia micrantha (Hochst.) Baill. is a small to medium sized tree belonging to the familyPhyllanthaceae, commonly known as mitzeerie or coastal golden leaf [1].The genus name “Bridelia” was coined in honour of Samuel Elisée Bridel-Brideri (1761–1828), a Swiss-German muscologist [2]
B. micrantha extracts are characterized by weak antiplasmodial activities [59,90,91], these results provide compelling evidence for the rationale of the species as malaria remedy in Guinea [57], Ivory Coast [58], Kenya [56] and Tanzania [20,59]
Summary
Bridelia micrantha (Hochst.) Baill. is a small to medium sized tree belonging to the family. The genus Bridelia includes approximately 60–70 species found throughout tropical and subtropical regions of the world, Africa and Asia [3,4]. Due medicinal to its popularity tree in Tanzania as a herbal [9]. B. micrantha is an important timber tree species in tropical Africa, and the handles in Ethiopia [1,14]. The present review isthe aimed atthe documenting the the validation of the ethnopharmacological uses of the species. Results of thi al activities and the uses, correlated biological chemical activities compounds and the correlated of micrantha chemical with compounds emphasis on of micrantha with emphasis on ethnomedicinal uses, biological activities and the correlated chemical compounds of B. micrantha with research challenges andofperspectives to address the knowledg of the ethnopharmacological the validation ofvalidation of thethe ethnopharmacological species.
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