Ethnopharmacological Investigation of Plants Used in the Treatment of Breast Cancer in Northern Cameroon

Abstract

IntroductionTherapeutic activities of medicinal plants are due to the different secondary metabolites, which are stored in their organs and constitute a large reservoir. These medicinal plants could allow the development of new biomolecules, which would constitute an alternative against highly toxic breast cancer chemotherapy. The present study identifies the medicinal plants used by the traditional medicine practitioners of the northern region of Cameroon in the treatment of this pathology. MethodsA semistructured questionnaire was used to collect sociodemographic information from participants as well as ethnobotanical and ethnopharmacological data of the different treatments. The approach used to conduct the survey was an interview with the traditional medicine practitioners of the region using the local language. ResultsAs a result, 131 traditional healers were interviewed; they provided 50 therapeutic recipes made from 37 plant species belonging to 21 families. The recipes presented are mainly formulated from a single plant (74%) while among the combinations, associating two plants was predominant (18%). The bark was the most used organ (46%) while the most used preparation methods were decoction (52%) and maceration (36%). Treatments were mainly administered orally for an unlimited duration (until recovery). The plants listed were found to be rich in secondary metabolites such as alkaloids, flavonoids, or tannins that revealed anticancer activities through literature. ConclusionsThe results of the present work constitute a strong basis for the search of new anticancer chemotherapeutic agents that would be more available and less invasive.