Abstract
Herbs orchestrate resurgence and vegetal awakening is supervened everywhere in the world. Medicinal plants always played an important role in the health development of mankind. Piper longum provides us new lead molecules for the development of drugs against various pharmacological targets. Plants included in this family are annual and persistent herbs or shrubs, indigenous to northern moderate stretch of the world. Piper longum is well known for its medicinal and pharmaceutical importance. In this review studies we will want to explore the various pharmacological properties of Piper longum in Unani system of medicine. Evidence suggests that various listed of Unani Medicine formulated with the Piper longum among these few are tablet, capsule, syrup and semi-solid etc. The primary constituents isolated from various parts of P. longum are piperine, piperlongumine, sylvatin, sesamin, diaeudesmin piperlonguminine, pipermonaline, and piperundecalidine. It is most commonly used to treat chronic bronchitis, asthma, constipation, gonorrhea, paralysis of the tongue, diarrhea, cholera, chronic malaria, viral hepatitis, respiratory infections, stomachache, bronchitis, diseases of the spleen, cough, and tumors. This study provides detailed information about the P. longum fruit, including phytochemistry, pharmacological profile and safety profile.
 Asian J. Med. Biol. Res. March 2019, 5(1): 1-7
Highlights
Plants play a major role in the discovery of new therapeutic agents
Active compounds derived from medicinal plants have been the basis for the development of new chemical leads for the pharmaceutical industry
Hepatoprotective activity Gurumurthy experimented with aqueous extract of fruits of P. longum and piperine were chosen to study their hepatoprotective potential on administration with normal doses of anti-tubercular drugs
Summary
Plants play a major role in the discovery of new therapeutic agents. They have received a lot of attention during these days for the isolation of biologically active substances for the cure of diseases. Plant based medicinal compounds is long established to be used as traditional treatment for innumerable human diseases from time immemorial in many parts of the world. It is still the primary source of medicine in rural areas of the developing countries (Chitme et al, 2004). Piper longum or Pipali which was mostly used for household cooking purposes as a spice and as seasoning now is a component of medicine as attested by several studies It is reported as good remedy for treating gonorrhea, menstrual pain, tuberculosis, sleeping problems, respiratory tract infections, chronic gut-related pain and arthritic conditions. Considering its significant effect on the bioavailability enhancing capability of drugs, it has potential to be used as an adjuvant with therapeutic drugs in chronic ailments, to reduce the effective dose of the drug intake reducing the subsequent adverse effects (Nagatome et al, 2005)
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