Abstract
Anthriscus sylvestris (L.) Hoffm. is a wild herbaceous plant common in most temperate regions. It has been used traditionally to treat headaches, as a tonic, as antitussive, antipyretic, analgesic and diuretic. The plant contains deoxypodophyllotoxin, which is proven to have antitumor and anti-proliferative effects, anti-platelet aggregation, antiviral, anti-inflammatory and insecticidal activity. Deoxypodophyllotoxin is considered to be the plant’s most important constituent, because of its pharmacological properties and because it can be converted into epipodophyllotoxin, the main raw material for the semisynthesis of the cytostatic agents etoposide and teniposide. This work summarizes for the first time the results related to the botanical description, distribution and habitat, phytochemical and pharmacological properties and emphasizes the aspects for future biotechnological research to establish its utility in the therapeutic arsenal.
Highlights
Anthriscus sylvestris (L.) Hoffm., known as wild chervil or cow parsley, belongs to the Apiaceae family and is a wild plant common in most temperate regions
Deoxypodophyllotoxin is considered to be the plant’s most important constituent, due to its pharmacological properties and because it can be used for the semisynthesis of podophyllotoxin and of the related cytostatic agents etoposide and teniposide [8]
In the attempt to understand the mechanisms accounting for its anti-inflammatory effects, deoxypodophyllotoxin was isolated from the methanol-dichloromethane extract of A. sylvestris root
Summary
Anthriscus sylvestris (L.) Hoffm., known as wild chervil or cow parsley, belongs to the Apiaceae family and is a wild plant common in most temperate regions. Related members of the Apiaceae include anise, carrot, celery, chervil, coriander, cumin, fennel, hemlock and parsley [1]. It is most commonly found in hedgerows and road verges, and on woodland edges, neglected pastures and hay meadows [2]. It have been used traditionally as antitussive, antipyretic, analgesic, diuretic, and a cough remedy [3]. Deoxypodophyllotoxin is considered to be the plant’s most important constituent, due to its pharmacological properties and because it can be used for the semisynthesis of podophyllotoxin and of the related cytostatic agents etoposide and teniposide [8]. The present review covers the available literature and offers systematic information for further studies on A. sylvestris and on its main lignan constituent
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