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Abstract
Daphne mucronata is a shrub well known as a medicinal plant in different regions of Asia. Ethnobotanical, phytochemical and pharmacological studies have revealed strong anti-cancer potential of the plant. Literature reports the evaluation of the initial bioactivity profile and extraction of the plant followed by different chromatographic techniques to obtain fractions. As an outcome, isolation and identification of coumarins, flavonoids, triterpenoids, lignin cumarinolignans, glucosides, daphnecin, aquillochin, daphnine and umbelliferone from the plant have been reported. Of these compounds, a diterpene, named gnidilatimonoein, has shown promising anticancer potency in in vitro tests on various cancer cell lines. This review article is an effort to summarize literature published in recent years on the bioactivity of Daphne mucronata.
Highlights
Ethnobotany is the principal approach to investigate natural resource management of native society
Daphne mucronata is a wild shrub of the Thymelaeaceae family and is distributed in Northern areas of Pakistan as well as in several regions of Iran and is considered as an important medicinal plant in these areas; it is well known for its ethno pharmacological importance and has been employed in conventional medication for the treatment of various diseases [1,2,3,4,5,6,7,8]
Daphne mucronata extract has the tendency to increase the release of TNF-α and down regulate the TNF-α receptor by a mechanism identical to toxic on cultured human monocytes [26,35]
Summary
Ethnobotany is the principal approach to investigate natural resource management of native society It is a science of human synergy with plants and ecosystem [1]. Thymelaeaceae family constitutes of 50 genera and 900 species that are mostly impound Asia, Africa and Australia It is typified in Pakistan by 5 genera and 7 species [2]. Daphne mucronata is a wild shrub of the Thymelaeaceae family and is distributed in Northern areas of Pakistan as well as in several regions of Iran and is considered as an important medicinal plant in these areas; it is well known for its ethno pharmacological importance and has been employed in conventional medication for the treatment of various diseases [1,2,3,4,5,6,7,8]. Its liniment is effective in treating infectious wounds, the plant material is ground and mixed with water to prepare the paste; a pain relieving effect has been observed when weary muscles are either exposed directly to the smoke of branches or steam of its water extract; its decoction and cooked leaves are employed for curing women infertility, gynecological problems, infections, menstruation disorders and constipation [7]
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