Abstract
BackgroundLow circulating 25 hydroxyvitamin D [25(OH)D] concentrations are common in obesity (BMI ≥30 kg/m2) and a negative relationship with body fat distribution has recently been reported. Ethnic-specific differences in body fat distribution have been described with South Asians are reported to have greater visceral adipose tissue (VAT), which could influence circulating 25(OH)D concentrations. The objective of this study is to investigate the relationship between plasma 25(OH)D, adiposity, and body fat distribution in Europeans and South Asians.Methods/Principal Findings187 Europeans and 192 South Asians were assessed for demographics, anthropometrics, and plasma 25(OH)D concentrations. Subcutaneous adipose tissue (SAT) and VAT were quantified by CT scan, and percent body fat by DEXA. Data were assessed by general linear models. South Asians had lower (P<0.001) plasma 25(OH)D concentrations and higher VAT (P = 0.04) than Europeans. Plasma 25(OH)D concentrations were negatively (P<0.05) associated with BMI, waist circumference, percent body fat, total adipose tissue, VAT, and SAT in unadjusted models and negatively (P<0.05) associated with VAT, SAT, and percent body fat after adjusting for BMI, ethnicity, age, and season of blood collection in males and females. When percent body fat, VAT, and SAT were included in the same model, only VAT remained negatively (P<0.05) associated with plasma 25(OH)D concentrations. Ethnicity remained significant in all models (P<0.001).ConclusionCompared to other adipose tissue compartments, VAT may have a distinct role in determining plasma 25(OH)D concentrations, which may account for the lower levels in South Asians.
Highlights
Low vitamin D status is associated with a number of adverse health outcomes including osteoporosis, certain cancers, autoimmune conditions, and more recently cardiovascular disease (CVD) [1]
Compared to other adipose tissue compartments, visceral adipose tissue (VAT) may have a distinct role in determining plasma 25(OH)D concentrations, which may account for the lower levels in South Asians
Plasma 25(OH)D concentrations were negatively associated with body mass index (BMI) (p,0.001), waist circumference (p = 0.015), total abdominal adipose tissue (p,0.001), VAT (p,0.001), Subcutaneous adipose tissue (SAT) (p,0.001), and percent total body fat (p,0.001) (Table 2)
Summary
Low vitamin D status is associated with a number of adverse health outcomes including osteoporosis, certain cancers, autoimmune conditions, and more recently cardiovascular disease (CVD) [1]. Low vitamin D status has been defined by the Institute of Medicine as a circulating 25(OH)D concentration ,50 nmol/L [2]; a concentration of 70–100 nmol/L has been suggested for optimal health [3]. Obesity, defined as a BMI $30 kg/m2, has been reported to be inversely associated with circulating 25(OH)D concentrations [4,8,9]. Low circulating 25 hydroxyvitamin D [25(OH)D] concentrations are common in obesity (BMI $30 kg/m2) and a negative relationship with body fat distribution has recently been reported. Ethnic-specific differences in body fat distribution have been described with South Asians are reported to have greater visceral adipose tissue (VAT), which could influence circulating 25(OH)D concentrations. The objective of this study is to investigate the relationship between plasma 25(OH)D, adiposity, and body fat distribution in Europeans and South Asians
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
