Abstract
SUMMARY Patients with newly diagnosed pulmonary tuberculosis were treated with a combination of ethionamide 1 gm. daily and isoniazid 400 mg. daily. Twenty-six patients were observed for at least six months and eight for at least one year. Clinical, radiologic, and bacteriologic progress was satisfactory in all these cases. Conversion of sputum was achieved in every case, and there was no evidence of emergence of bacterial resistance to either drug. The incidence of ethionamide toxicity which occurred, however, indicates that a daily dose of 1 gm. of the drug is too high for routine use. Side effects observed were nausea, jaundice, mental disturbance, and peripheral neuritis. The excellent results in patients who could tolerate the ethionamide-isoniazid therapy warrant further trial of this drug combination, since the use of a lower dosage level of ethionamide may make it acceptable in regard to toxicity without sacrificing its therapeutic effectiveness.
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