Abstract

Admission of patients with hematological malignancies to intensive care unit (ICU) raises recurrent ethical issues for both hematological and intensivist teams. The decision of transfer to ICU has major consequences for end of life care for patients and their relatives. It also impacts organizational human and economic aspects for the ICU and global health policy. In light of the recent advances in hematology and critical care medicine, a wide multidisciplinary debate has been conducted resulting in guidelines approved by consensus by both disciplines. The main aspects developed were (i) clarification of the clinical situations that could lead to a transfer to ICU taking into account the severity criteria of both hematological malignancy and clinical distress, (ii) understanding the process of decision-making in a context of regular interdisciplinary concertation involving the patient and his relatives, (iii) organization of a collegial concertation at the time of the initial decision of transfer to ICU and throughout and beyond the stay in ICU. The aim of this work is to propose suggestions to strengthen the collaboration between the different teams involved, to facilitate the daily decision-making process, and to allow improvement of clinical practice.

Highlights

  • Admission of patients with hematological malignancies to intensive care unit (ICU) raises recurrent ethical issues for both hematological and intensivist teams

  • It has been reported that 7% of all new cases of hematological malignancies and up to 15% of acute myeloid leukemia may justify a transfer to ICU [11, 12]

  • On the other hand, increased requests for transfer to ICU for patients who will not benefit from this highly technological environment are not desirable [32, 40, 41]. To avoid these extreme situations, we propose to distinguish medical situations when hematologists should consider a transfer to intensive care units according to the expected evolution of the underlying condition, while knowing that there can be no rigid criteria to send patients to ICU and that this decision has to be individualized [13, 20]

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Summary

Current Situation

Therapeutic advances regarding hematological malignancies allow the care of an increased number and older patients and improve the chances of cure or prolonged remissions [1,2,3,4,5,6,7]. Advances in life-sustaining therapies improve the management of these patients, with increased knowledge of Advances in Hematology the chances of reversibility and of the risk factors of unfavorable outcomes [14,15,16,17,18,19,20], but mortality in this group of patients still ranges from 33 to 58% [14, 21,22,23,24,25]. The collaboration of the teams of hematology and intensive care should improve the necessary collegial decision-making process whose traceability is mandatory

The Views of Hematologists
The Views of Intensivist Physicians
Decision-Making Process
Organization of the Concertation and Beyond
Findings
Conclusion
Full Text
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